Association and functional study of ATP6V1D and GPHN gene polymorphisms with depression in Chinese population

doi:10.5498/wjp.v15.i4.102182

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Apr 19, 2025 (publication date) through Mar 28, 2025

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World Journal of Psychiatry

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World J Psychiatry. Apr 19, 2025; 15(4): 102182
Published online Apr 19, 2025. doi: 10.5498/wjp.v15.i4.102182

Table 3 Association of the rs3759755, rs10144417, rs2031564, rs8020095 and rs8016024 polymorphisms with depression risk, n (%)

Models	Polymorphisms	Controls (n = 509)	Patients (n = 555)	Adjusted OR (95%CI)¹	P value
rs10144417
Codominant	A/A	151 (29.7)	195 (35.1)	1.00	-
	A/G	270 (53.0)	260 (46.9)	0.71 (0.53-0.94)	0.015
	G/G	88 (17.3)	100 (18.0)	0.81 (0.56-1.18)	0.270
Dominant	A/A	151 (29.7)	195 (35.1)	1.00	-
Dominant	A/G-G/G	358 (70.3)	360 (64.9)	0.73 (0.56-0.95)	0.021
Recessive	A/A-A/G	421 (82.7)	455 (82.0)	1.00	-
Recessive	G/G	109 (17.3)	100 (18.0)	1.01 (0.73-1.40)	0.940
Allele	A	572 (56.2)	650 (58.6)	1.00	-
Allele	G	446 (43.8)	460 (41.4)	0.87 (0.73-1.04)	0.130
rs2031564
Codominant	G/G	126 (24.8)	148 (26.7)	1.00	-
	G/A	263 (51.7)	270 (48.6)	0.82 (0.61-1.11)	0.200
	A/A	120 (23.6)	137 (24.7)	1.15 (0.80-1.64)	0.450
Dominant	G/G	126 (24.8)	148 (26.7)	1.00	-
Dominant	G/A-G/G	383 (75.2)	407 (73.3)	0.84 (0.63-1.12)	0.230
Allele	A	572 (56.0)	650 (59.0)	1.00	-
Allele	G	446 (44.0)	460 (41.0)	1.06 (0.89-1.27)	0.510
rs3759755
Codominant	A/A	155 (30.5)	196 (35.3)	1.00	-
	A/C	270 (53.0)	259 (46.7)	0.71 (0.54-0.95)	0.081
	C/C	84 (16.5)	100 (18.0)	0.88 (0.60-1.27)	0.490
Dominant	A/A	155 (30.5)	196 (35.3)	1.00	-
Dominant	A/C-C/C	354 (69.5)	359 (64.7)	0.75 (0.58-0.98)	0.036
Recessive	A/A-A/C	425 (83.5)	455 (82.0)	1.00	-
Recessive	C/C	84 (16.5)	100 (18.0)	1.08 (0.78-1.50)	0.650
Allele	A	580 (57.0)	651 (58.6)	1.00	-
Allele	C	438 (43.0)	459 (41.4)	0.90 (0.75-1.07)	0.240
rs8016024
Codominant	T/T	131 (25.7)	158 (28.5)	1.00	-
	T/C	260 (51.1)	264 (47.6)	0.79 (0.58-1.06)	0.110
	C/C	118 (23.2)	133 (24.0)	0.83 (0.58-1.19)	0.310
Dominant	T/T	131 (25.7)	158 (28.5)	1.00	-
Dominant	T/C-C/C	378 (74.3)	397 (71.5)	0.80 (0.61-1.06)	0.120
Allele	T	522 (51.0)	580 (52.0)	1.00	-
Allele	C	496 (49.0)	530 (48.0)	0.91 (0.77-1.09)	0.320
rs8020095
Codominant	G/G	125 (24.6)	164 (29.5)	1.00	-
	G/A	274 (53.8)	285 (51.4)	0.72 (0.53-0.97)	0.028
	A/A	110 (21.6)	106 (19.1)	0.66 (0.45-0.95)	0.025
Dominant	G/G	125 (24.6)	164 (29.5)	1.00	-
Dominant	G/A-A/A	384 (75.4)	391 (70.5)	0.70 (0.53-0.93)	0.013
Recessive	G/G-G/A	399 (78.4)	449 (80.9)	1.00	-
Recessive	A/A	110 (21.6)	106 (19.1)	0.82 (0.60-1.12)	0.210
Allele	A	494 (48.5)	497 (44.8)	1.00	-
Allele	G	524 (51.5)	613 (55.2)	1.23 (1.03-1.46)	0.023

¹Odds ratio was adjusted by age and gender.

OR: Odds ratio; CI: Confidence interval.

Citation: Liang P, Chen JJ, Yang X, Long R, Li Y, Wang ZL, Yang PL, Liang YD. Association and functional study of ATP6V1D and GPHN gene polymorphisms with depression in Chinese population. World J Psychiatry 2025; 15(4): 102182
URL: https://www.wjgnet.com/2220-3206/full/v15/i4/102182.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i4.102182