Voxel-based alterations in spontaneous brain activity among very-late-onset schizophrenia-like psychosis: A preliminary resting-state functional magnetic resonance imaging study

Figure 1 Brain regions with significant differences in amplitude of low-frequency fluctuations, fractional amplitude of low-frequency fluctuations, regional homogeneity, and voxel-mirrored homotopic connectivity between the very-late-onset schizophrenia-like psychosis and healthy controls groups, corrected using Gaussian random field (voxel P < 0. 001, cluster P < 0.01). A: Compared with healthy controls (HCs), the very-late-onset schizophrenia-like psychosis (VLOSLP) group showed decreased amplitude of low-frequency fluctuations (ALFF) values in the left cuneus, right precuneus, right precentral gyrus and left paracentral lobule; B: Compared with HCs, the VLOSLP group showed increased fractional ALFF values in the left caudate nucleus and decreased fractional ALFF values in the right calcarine fissure and surrounding cortex and right precuneus; C: Compared with HCs, the VLOSLP group showed increased regional homogeneity values in the right putamen; D: Compared with HCs, the VLOSLP group showed decreased voxel-mirrored homotopic connectivity values in the bilateral calcarine fissure and surrounding cortex (clusters A, B, C, and D), bilateral superior temporal gyrus, and bilateral cuneus. The colored bars show t values. ALFF: Amplitude of low-frequency fluctuations; fALFF: Fractional amplitude of low-frequency fluctuations; ReHo: Regional homogeneity; VMHC: Voxel-mirrored homotopic connectivity.