Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination

Figure 8 The voltage-gated proton channel 1 gene knockout inhibits interleukin-1β in diabetic mice by suppressing the glucose-regulated protein 78 pathway. The microglial cells in the diabetic group exhibited elevated interleukin (IL)-1β levels compared to the control, which were restored the voltage-gated proton channel 1 (Hv1) knockout. Treatment with YUM70 enhanced the effect of Hv1 knockout, indicating that Hv1 knockout inhibits IL-1β by suppressing the glucose-regulated protein 78 pathway. ^dP < 0.05. The scale bar = 50 μm. Hv1: The voltage-gated proton channel 1; Iba-1: Ionized calcium-binding adaptor molecule 1; IL: Interleukin; DB: Diabetic group.