Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination

Figure 4 The voltage-gated proton channel 1 gene knockdown improved oligodendrocyte progenitor cell apoptosis in diabetic mice. A-L: The terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay results showing the apoptosis levels of neuro-glia antigen 2-positive oligodendrocyte precursor cells (OPCs) compared with the control group. The number of OPCs significantly decreased after five weeks; The scale bar = 50 μm; M: The voltage-gated proton channel 1 gene knockdown reduced OPC apoptosis. ^dP < 0.05. NG2: Neuro-glia antigen 2; DB: Diabetic group; Hv1: The voltage-gated proton channel 1.