Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination

Figure 1 The voltage-gated proton channel 1 gene deletion alleviates early cognitive impairment induced by diabetes. A: Blood glucose levels during glucose tolerance tests (n = 4 per group); B: Blood glucose levels during insulin tolerance tests (n = 4 per group); C: Working memory errors (n = 6 per group); D: In the eight-arm radial maze test, the voltage-gated proton channel 1-/- diabetic group mice made more different arm choices in the first eight entries than DB mice (n=6 per group). GTT: Glucose tolerance tests; ITT: Insulin tolerance tests; DB: Diabetic group; Hv1: The voltage-gated proton channel 1.