Mood symptoms, cognitive function, and changes of brain hemodynamics in patients with COVID-19: A functional near-infrared spectroscopy study

Figure 3 Group comparison of functional connectivity network. A-D: Group-averaged functional connectivity (FC) matrix in the uninfected group (A) and infected group (B) and statistical t-value matrix (C) and statistical t-value (false discovery rate) matrix (D) shown in Figure 3 channels were rearranged according to six regions of interest (Broca-left (L), dorsolateral prefrontal cortex-L [DLPFC-L], frontopolar area-L [FPA-L], FPA-R, DLPFC-R, Broca-R). In the group-averaged FC matrix, each pixel in the FC matrix maps had the Pearson correlation coefficient r value of the channel pairs, and the warm and cool colors indicated a positive and negative correlation, respectively. In Figure 3C, the two-sample t-test for the uninfected group and infected group was performed (without false discovery rate correction), and P-values were at 0.05 threshold, so any channel pairs’ t-value corresponding to the P-value greater than 0.05 were defined as 0. Figure 3D shows the false discovery rate correction result, and t-values of channel pairs not preserved after false discovery rate correction were defined as 0.