Sodium channel mutation SCN1A T875M, D188V and associated dysfunction with drug resistant epilepsy

doi:10.5498/wjp.v15.i2.100738

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Feb 19, 2025 (publication date) through Mar 22, 2025

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World Journal of Psychiatry

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World J Psychiatry. Feb 19, 2025; 15(2): 100738
Published online Feb 19, 2025. doi: 10.5498/wjp.v15.i2.100738

Table 2 Distribution of SCN1A rs121917953 T/A* and SCN1A rs121918623 C/T* polymorphisms in patients with drug-responsive vs drug-resistant epilepsy, n (%)

SCN1A rs121917953 T/A*				SCN1A rs121918623 C/T*
Genotype	Drug-responsive, n = 52	Drug-resistant, n = 43	P value	Genotype	Drug-responsive, n = 41	Drug-resistant, n = 47	P value
TT	18 (34.6)	6 (13.9)	0.001^a	CC	39 (95.1)	43 (91.4)	1.00^b
AT	33 (63.4)	36 (83.7)		CT	1 (2.4)	4 (8.5)
AA	1 (1.9)	1 (2.3)		TT	1 (2.4)	0 (0)

^aP value calculated using χ² test.

^bP value calculated using Fisher’s exact test, P < 0.05 is considered significant.

Citation: Dabla PK, Gupta S, Singh S, Viswas A, Yadav M, Sonkar SC, Koner BC. Sodium channel mutation SCN1A T875M, D188V and associated dysfunction with drug resistant epilepsy. World J Psychiatry 2025; 15(2): 100738
URL: https://www.wjgnet.com/2220-3206/full/v15/i2/100738.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i2.100738