Effect of quantitative consciousness index on seizure parameters during electroconvulsive therapy in patients with major depressive disorder

Table 2 Generalized linear mixed model examining effect of treatment, patient, and anesthesia factors on electroencephalography seizure parameters

Covariate/dependent	EEG endpoint (s)			ASEI (μV2)			PSI (%)			Mid-ictal amplitude (μV)			Coherence (%)			Maximum heart rate, (bpm)			Recovery time (min)
	Est	SE	P value	Est	SE	P value	Est	SE	P value	Est	SE	P value	Est	SE	P value	Est	SE	P value	Est	SE	P value
qCON	0.339	0.160	0.036a	34.150	140.526	0.808	0.057	0.095	0.553	0.531	0.232	0.023a	0.096	0.062	0.125	0.331	0.140	0.019a	-0.017	0.039	0.664
qNOX	-0.011	0.116	0.922	-2.927	116.196	0.980	0.162	0.079	0.042a	0.216	0.191	0.259	0.001	0.051	0.988	0.061	0.114	0.593	0.022	0.029	0.457
Age (years)	-0.597	0.213	0.006a	142.879	94.214	0.131	-0.079	0.063	0.211	-0.064	0.162	0.693	0.034	0.046	0.456	0.091	0.104	0.384	0.096	0.046	0.039a
ECT number	-	-	0.000a	-	-	0.000a	-	-	0.024a	-	-	0.418	-	-	0.158	-	-	0.128	-	-	0.266
Charge, mC	0.068	0.667	0.307	-32.539	30.452	0.287	0.014	0.020	0.491	0.032	0.052	0.545	-0.007	0.015	0.647	-0.024	0.034	0.483	0.002	0.015	0.888
Anesthetic-ECT time, interval (min)	0.157	0.048	0.001a	-17.207	43.983	0.696	0.072	0.030	0.018a	0.041	0.073	0.575	0.007	0.020	0.724	0.074	0.044	0.093	-0.001	0.012	0.922

^aP < 0.05.

Est: Estimate; SE: Standard error; EEG endpoint: Electroencephalograph seizure duration; ASEI: Average seizure energy index; PSI: Post-ictal suppression index; qCON: Quantitative consciousness; qNOX: Quantitative nociceptive; ECT: Electroconvulsive therapy.