Predictive effect of lipopolysaccharide-stimulated inflammatory cytokines on symptoms of generalized anxiety disorder

Table 4 Correlation between inflammatory factors and Hamilton Anxiety Rating Scale scores

Inflammatory factor	Correlation with HAMA scores before LPS stimulation		Correlation with HAMA scores after LPS- stimulation
	r value	P value	r value	P value
IL-1β	0.118	0.271	0.219	0.039
IL-2	0.131	0.220	-0.20	0.852
IL-4	0.106	0.322	0.663	0.558
IL-5	-0.087	0.420	-0.042	0.698
IL-6	0.058	0.590	0.379	< 0.001
IL-8	0.149	0.164	0.640	< 0.001
IL-10	0.050	0.640	-2.92	0.005
TNF-α	0.108	0.313	0.621	< 0.001
IFN-γ	0.049	0.647	0.153	0.151
IL-17A	0.245	0.021	0.138	0.197
IL-12p70	0.118	0.270	0.091	0.399
IFN-α	0.036	0.737	0.144	0.178

IFN: Interferon; IL: Interleukin; TNF: Tumor necrosis factor; HAMA: Hamilton Anxiety Rating Scale; LPS: Lipopolysaccharide.