Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study

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Aug 19, 2024 (publication date) through Aug 13, 2024

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Psychiatry. Aug 19, 2024; 14(8): 1244-1253
Published online Aug 19, 2024. doi: 10.5498/wjp.v14.i8.1244

Table 2 Inverse variance weighting meta-analysis of mendelian randomization estimates for interleukin-6 receptor blockade in epilepsy

Trait	OR (95%CI)	P value	Case/control
Epilepsy	0.827 (0.685-1.000)	0.050	28103/342480
Generalized epilepsy	0.822 (0.532-1.272)	0.380	5182/428964
Focal epilepsy	0.834 (0.648-1.075)	0.161	17197/428967
Juvenile absence epilepsy	0.987 (0.941-1.036)	0.609	415/29677
Juvenile myoclonic epilepsy	0.967 (0.896-1.044)	0.393	1181/29677
Childhood absence epilepsy	0.984 (0.923-1.049)	0.616	793/29677

OR: Odds ratio; CI: Confidential interval.

Citation: Yu YM, Jin GH, Zhong C, Qian H, Wang L, Zhan F. Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study. World J Psychiatry 2024; 14(8): 1244-1253
URL: https://www.wjgnet.com/2220-3206/full/v14/i8/1244.htm
DOI: https://dx.doi.org/10.5498/wjp.v14.i8.1244