Effects of hormone replacement therapy on mood and sleep quality in menopausal women

Table 2 Comparison of symptom improvement between the two groups

Content	Time	Control, n = 76	Observation, n = 76	t value	P value
Hot flashes and sweating	Pre-treatment	8.35 ± 1.27	8.20 ± 1.32	0.714	0.476
	Post-treatment	4.24 ± 1.18a	3.78 ± 1.09a	2.496	0.014
Abnormal sensations	Pre-treatment	3.52 ± 0.47	3.43 ± 0.50	1.143	0.255
	Post-treatment	2.05 ± 0.36a	1.93 ± 0.24a	2.418	0.017
Insomnia	Pre-treatment	3.23 ± 0.61	3.35 ± 0.58	1.243	0.216
	Post-treatment	2.14 ± 0.43a	1.98 ± 0.32a	2.602	0.010
Agitation	Pre-treatment	3.12 ± 0.45	3.03 ± 0.37	1.347	0.180
	Post-treatment	1.69 ± 0.28a	1.60 ± 0.15a	2.470	0.015
Depression	Pre-treatment	1.87 ± 0.36	1.90 ± 0.42	0.473	0.637
	Post-treatment	1.15 ± 0.19a	1.09 ± 0.10a	2.436	0.016
Vertigo	Pre-treatment	1.41 ± 0.29	1.38 ± 0.27	0.660	0.510
	Post-treatment	1.01 ± 0.17a	0.95 ± 0.08a	2.784	0.006
Bone and joint pain/muscle pain	Pre-treatment	1.93 ± 0.35	1.87 ± 0.40	0.984	0.327
	Post-treatment	1.31 ± 0.22a	1.24 ± 0.09a	2.567	0.011
Headaches	Pre-treatment	1.61 ± 0.53	1.58 ± 0.60	0.327	0.744
	Post-treatment	1.02 ± 0.34a	0.90 ± 0.23a	2.549	0.012
Fatigue	Pre-treatment	1.73 ± 0.42	1.68 ± 0.37	0.779	0.437
	Post-treatment	1.19 ± 0.30a	1.08 ± 0.24a	2.496	0.014
Palpitations	Pre-treatment	1.49 ± 0.38	1.52 ± 0.43	0.456	0.649
	Post-treatment	0.83 ± 0.25a	0.74 ± 0.19a	2.499	0.014
Crawling sensation of the skin	Pre-treatment	1.17 ± 0.26	1.22 ± 0.30	1.098	0.274
	Post-treatment	0.73 ± 0.18a	0.67 ± 0.10a	2.540	0.012
Sexuality	Pre-treatment	3.47 ± 0.58	3.38 ± 0.61	0.932	0.353
	Post-treatment	2.03 ± 0.35a	1.90 ± 0.24a	2.671	0.008
Urinary tract infection	Pre-treatment	3.02 ± 0.49	3.06 ± 0.54	0.478	0.633
	Post-treatment	1.88 ± 0.36a	1.75 ± 0.27a	2.518	0.013

^aP < 0.05 compared with this group before treatment.

Data are mean ± SD.