This pain drives me crazy: Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

Table 2 Studies emerging from searching the ClinicalTrials.gov site on the November 7, 2023. Strategy used: Condition/disease: Interstitial cystitis; Other terms: Psychological symptoms; Intervention/treatment: blank (not required)

Study title	NCT number	Dates	Status	Conditions	Interventions	Sponsor	Responsible	Results	Study type	Ref.
Smartphone-based Self-care Education Program for Women with Interstitial Cystitis: Educational Remote IC Aide	NCT05260112	February 17, 2022 Last, April 1, 2023	Completed	Cystitis, Interstitial	Other: ERICA	University of Pennsylvania, Philadelphia, PA, United States	Edward Kim	Submitted March 31, 2023, quality control still not concluded	Interventional	None
Interstitial Cystitis: Monitoring of the Psychic State and Counseling Intervention in the COVID-19 Era	NCT05752344	February 28, 2023	Completed	Cystitis, Interstitial	Other: Counselling	Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy	Marianna Mazza	Not submitted; study conducted from November 1, 2020 to November 1, 2022	Observational	None
Safety and Efficacy of Aloe Vera in the Management of the Symptoms of Interstitial Cystitis	NCT04734106	February 1, 2021 Last, January 24, 2024	Not yet recruiting	Interstitial Cystitis Chronic Interstitial Cystitis Bladder Pain Syndrome	Drug: Desert Harvest Aloe Vera Capsules Other: Placebo Capsules	Wake Forest University Health Sciences, Winston-Salem, N.C., United States	Wake Forest University Health Sciences	Not started	Interventional	None
Biopsychosocial and Conventional Approach in Bladder Pain Syndrome	NCT05155384	December 10, 2021 Last, January 3, 2022	Unknown status	Interstitial Cystitis/Bladder Pain Syndrome, Randomised Control Trial	Other: Pain Neuroscience Education; Relaxation exercises; Cognition target exercise; Pelvic floor stretching exercises; Transcutaneous electrical nerve stimulation	Hacettepe University, Ankara, Turkey	Ceren Gursen	Some results submitted; quality control still not concluded; completion estimated October 15, 2022; no notice since then	Interventional	None
Study of Biomarkers and the Relaxation Response Using Guided Imagery in Women With IC	NCT00420550	September 1, 2007, Last March 21, 2012	Completed	Interstitial Cystitis Pelvic Pain	Behavioural: Relaxation Response using Guided Imagery, Phase 2	William Beaumont Hospitals, Royal Oak, MI, United States	Kenneth Peters	No results posted	Interventional	None
Quality of Life Analysis in Bladder Pain Syndrome/Interstitial Cystitis	NCT05630742	November 18, 2022, Last November 30, 2022	Completed	Interstitial Cystitis, Bladder Pain Syndrome, Quality of Life	Other: chronic non-neoplastic pain	IRCCS Policlinico S. Matteo, Pavia, Italy	Daniele Porru	Results not posted	Observational	Porru et al[75]
Identifying Predictors of Treatment Success in Painful Bladder Syndrome	NCT01410461	August 4, 2011, Last August 5, 2011	Unknown status	Painful Bladder Syndrome	Device: quantitative sensory testing; Ultrasound testing	Rambam Health Care Campus, Haifa, Israel	Lior Lowenstein, Dalia Kesner	No results posted	Observational	None
Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome	NCT04401176	May 19, 2020, Last October 12, 2023	Completed	Interstitial Cystitis Bladder Pain Syndrome	Drug: Heparin & Alkalinized Lidocaine Bladder Instillation; Onabotulinum Toxin A, Phase 2	Walter Reed National Military Medical Center, Bethesda, Maryland, United States	Eva Kwong Welch	No results posted	Interventional	None
Interstitial Cystitis: Elucidation of the Psychophysiologic and Autonomic Characteristics (ICEPAC) Study	NCT01616992	June 8, 2012, Last February 4, 2015	Completed	Interstitial Cystitis/Painful Bladder Syndrome Myofascial Pelvic Pain	Drug: Bupivacaine	Case Western Reserve University, Cleveland, Ohio, United States	Thomas C Chelimsky, Medical College of Wisconsin; Jeffrey Janata, University Hosp. Cleveland	Results not posted	Observational	Williams et al[150]
Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments	NCT03844412	February 15, 2019, Last November 29, 2023	Recruiting	Vestibulodynia Temporomandibular Disorder Fibromyalgia Syndrome	Drug: 5% lidocaine/5 mg/ml 0.02% oestradiol compound cream; Nortriptyline; Placebo cream	Duke University, Durham, North Carolina, United States	Andrea Nackley – Duke, Andrea Rapkin – UCLA, Erin Carey-Elizabeth Geller – Duke	To be completed on December 1, 2024 (estimated)	Interventional	None
Translational Research in Pelvic Pain	NCT04001244	May 16, 2019, Last April 4, 2023	Completed	Endometriosis Bladder Pain Syndrome/Chronic Pain	Differentiate between two types of pelvic pain condition (endometriosis-associated pain and bladder pain syndrome)	University of Oxford, United Kingdom – IBMC Porto, Portugal – Boston Children's Hospital - Michigan State University – Bayer Grünenthal GmbH – Esteve – Queen Mary University of London – Aalborg University – Endometriosis.org – International Painful Bladder Foundation – Pelvic Pain Support Network – King's College London – Universität Heidelberg – University of Edinburgh – Universität Jena – Universität Münster	Katy Vincent – University of Oxford	No results posted	Observational	Dimitriou et al[149]
Life-Stress Interview for Women With Chronic Urogenital Pain Conditions	NCT02286115	November 5, 2014, Last December 14, 2016	Completed	Chronic Urogenital Pain	Behavioural: Life-Stress Interview	William Beaumont Hospitals, Royal Oak, MI, United States	Jennifer Carty, Mark A. Lumley – Wayne State University	No results posted	Interventional	Imamura et al[151]; mentioned in Carty et al[152] and Carty[153]
Improving Female Sexual Wellness	NCT04824820	March 29, 2021, Last April 5, 2023	Completed	Urinary Incontinence, Sexual Dysfunction, Pelvic Organ Prolapse, Pelvic Floor Disorders, Interstitial Cystitis, Female Sexual Dysfunction, Hypoactive Sexual Desire Disorder, Sexuality Orgasmic Disorder, Sexual Desire Disorder	Behavioural: Vibrator	Cedars-Sinai Medical Center, Los Angeles, CA, United States	Karyn Eilber, principal investigator; contact: Alexandra Dubinskaya	No results posted	Interventional	None
Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions	NCT01953523	September 2, 2013, Last September 25, 2018	Completed	Neurodegenerative Diseases Osteoarthritis, Erectile Dysfunction, Autoimmune Diseases, Cardiomyopathies, Emphysema	Procedure: Administration of autologous adipose derived SVF	Elliot Lander, Rancho Mirage, CA, United States	Mark H Berman	Completed January 1, 2017; No results posted	Interventional	Wyles et al[154] and Khera et al[155]

Data from ClinicalTrials.gov and internet searches.