Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia

Table 4 Correlations of negative symptoms with information, similarities in catechol-O-methyltransferase met-carriers and Val homozygotes

			Information	Similarities
PANSS negative	Met-carriers (n = 27)	r value	-0.099	-0.223
		P value	0.624	0.263
	Val/Val (n = 27)	r value	-0.544	-0.62
		P value	0.003	0.001
	Correlation coefficient comparison	Z value	1.768	1.726
		P value	0.038	0.042
	Interaction test1	β value	-0.282	-0.250
		95%CI	-0.552 to -0.011	-0.495 to -0.004
		P value	0.042	0.046

¹In the multiple linear regression, negative symptoms were treated as the dependent variable, with catechol-O-methyltransferase (COMT) genotype, information or similarities, the product of COMT genotype and information or similarities, gender, and chlorpromazine equivalents serving as independent variables.

PANSS: Positive and negative syndrome scale.