Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China

Table 3 Correlation of average concentrations of risperidon + 9-hydroxyrisperidone in plasma/(dose × kg) according to sex with clinical and psychopathological variables

Correlation of average concentration in plasma/(dose × kg) with	Correlation coefficient	P value
Male (n = 32)
Age (yr)	0.4572	0.008
Number of cigarettes (smokers)	-0.3591	0.092
Systolic blood pressure	0.0962	0.600
Diastolic blood pressure	0.1262	0.492
BMI	-0.2711	0.134
Heart rate	-0.1731	0.344
QTc	0.0602	0.743
Mean PANSS positive scale score	0.1792	0.328
Mean PANSS negative scale score	0.3731	0.035
Mean PANSS general psychopathology subscale score	0.3891	0.028
Mean PANSS total score	0.4812	0.005
Female (n = 18)
Age	0.4361	0.071
Systolic blood pressure	-0.1732	0.492
Diastolic blood pressure	0.0242	0.925
BMI	-0.4462	0.064
Heart rate	0.1322	0.600
QTc	0.0592	0.816
Mean PANSS positive subscale score	-0.2541	0.310
Mean PANSS negative subscale score	-0.1302	0.607
Mean PANSS general psychopathology subscale score	0.3752	0.125
Mean PANSS total score	0.0642	0.801

¹Spearman’s correlation coefficient.

²Pearson’s correlation coefficient.

BMI: Body mass index; QTc: QT interval; PANSS: Positive and Negative Syndrome Scale; PHQ-9: Patient Health Questionnaire Depression Scale.