Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China

Table 2 Risperidone dose and plasma concentrations of risperidone and 9 hydroxyrisperidone according to sex

	Sex	n	Average	SD	P value
Risperidone dose (mg)1	Male	32	4.09	1.12	0.003
	Female	18	3.11	0.90
	Total	50	3.74	1.14
Risperidone dose per kg weight2	Male	32	0.06	0.02	0.010
	Female	18	0.05	0.02
	Total	50	0.06	0.02
Concentration of risperidone in plasma (ng/mL)1	Male	32	8.61	10.80	0.134
	Female	18	15.13	15.27
	Total	50	10.96	12.83
Concentration of 9-hydroxyrisperidone in plasma (ng/mL)1	Male	32	32.37	18.63	0.887
	Female	18	29.24	10.25
	Total	50	31.24	16.07
Concentration of risperidone + 9-hydroxyrisperidone in plasma (ng/mL)1	Male	32	40.98	23.98	0.293
	Female	18	44.37	18.79
	Total	50	42.20	22.11
Concentration of risperidone + 9-hydroxyrisperidone in plasma/dose2	Male	32	9.87	4.18	0.010
	Female	18	14.89	6.96
	Total	50	11.68	5.81
Concentration of risperidone + 9-hydroxyrisperidone in plasma/(dose × kg)1	Male	32	0.16	0.07	0.017
	Female	18	0.24	0.12
	Total	50	0.18	0.10

¹Mann-Whitney U-test.

²Student's t-test.