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©The Author(s) 2024.
World J Psychiatry. Mar 19, 2024; 14(3): 370-379
Published online Mar 19, 2024. doi: 10.5498/wjp.v14.i3.370
Published online Mar 19, 2024. doi: 10.5498/wjp.v14.i3.370
Table 1 Baseline characteristics of non-brain injured patients, n (%)
| Dexmedetomidine (n = 52) | Propofol (n = 63) | P value | |
| Age (yr), median (IQR) | 61.0 (55.0-64.0) | 61.0 (53.0-66.0) | 0.663 |
| Male | 30 (57.7) | 39 (61.9) | 0.646 |
| BMI (kg/m2), median (IQR) | 21.8 (19.6-24.3) | 21.1 (19.0-22.3) | 0.191 |
| SAPS II, median (IQR) | 46.0 (38.0-54.0) | 46.0 (36.0-53.0) | 0.675 |
| Main reason for ICU | |||
| Medical | 37 (71.2) | 44 (69.9) | 0.983 |
| Surgical | 10 (19.2) | 13 (20.6) | |
| Trauma | 5 (9.6) | 6 (9.5) | |
| Infection at ICU admission | 24 (46.2) | 30 (47.6) | 0.875 |
| SOFA score of organ > 2 | |||
| Respiratory | 30 (57.7) | 35 (55.6) | 0.818 |
| Cardiovascular | 26 (50.0) | 27 (42.9) | 0.444 |
| Renal | 8 (15.4) | 10 (15.9) | 0.943 |
| Coagulation | 4 (7.7) | 6 (9.5) | 0.729 |
| Liver | 1 (1.9) | 1 (1.6) | 0.891 |
| Total SOFA score, median (IQR) | 7.0 (4.0-9.0) | 6.0 (3.0-9.0) | 0.954 |
| RASS score at enrollment, median (IQR) | -2 (-3 to -1) | -3 (-3 to -1) | 0.247 |
| Time from ICU admission to drug initiation (h), median (IQR) | 32.0 (20.0-35.0) | 31.0 (20.0-42.0) | 0.798 |
- Citation: Yuan HX, Zhang LN, Li G, Qiao L. Brain protective effect of dexmedetomidine vs propofol for sedation during prolonged mechanical ventilation in non-brain injured patients. World J Psychiatry 2024; 14(3): 370-379
- URL: https://www.wjgnet.com/2220-3206/full/v14/i3/370.htm
- DOI: https://dx.doi.org/10.5498/wjp.v14.i3.370