Interaction between serum inflammatory cytokines and brain-derived neurotrophic factor in cognitive function among first-episode schizophrenia patients

Table 4 Multiple linear regression analysis of factors affecting the degree of cognitive impairment in first-episode schizophrenia patients

Dependent variable		Non standardized coefficient		Standard coefficient	t value	P value	95%CI of B
		B	Standard error	β			Lower limit	Upper limit
Information processing speed	Constant	35.834	5.378		6.663	0.000	25.134	46.535
	BDNF	0.002	0.002	0.156	1.396	0.167	-0.001	0.005
	IL-6	-0.173	0.088	-0.218	-2.039	0.046	-0.349	0.003
Attention	Constant	61.450	7.025		8.747	0.000	47.473	75.428
	IL-6	-0.492	0.114	-0.426	-4.329	0.000	-0.718	-0.266
	IL-1β	-0.312	0.155	-0.199	-2.019	0.047	-0.619	-0.005
Working memory	Constant	48.866	9.263		5.276	0.000	30.433	67.300
	IL-1β	-0.230	0.150	-0.155	-1.532	0.129	-0.529	0.069
	BDNF	0.004	0.002	0.192	1.793	0.077	0.000	0.008
	IL-6	-0.350	0.115	-0.321	-3.039	0.003	-0.580	-0.121
Comprehensive + execution ability	Constant	52.628	8.983		5.858	0.000	34.751	70.505
	IL-1β	-0.394	0.146	-0.261	-2.699	0.008	-0.684	-0.103
	BDNF	0.004	0.002	0.209	2.041	0.045	0.000	0.008
	IL-6	-0.362	0.112	-0.327	-3.242	0.002	-0.585	-0.140

BDNF: Brain derived neurotrophic factor; IL: Interleukin.