Association between intercellular adhesion molecule-1 to depression and blood-brain barrier penetration in cerebellar vascular disease

Table 2 Correlation between depression and cognitive functioning among cerebral small vessel disease patients

Characteristics	Depression (n = 53)	Non depression (n = 27)	P value
Age (years)	62.28 ± 7.83	60.52 ± 5.47	0.298
Male, n (%)	21 (39.6)	12 (44.4)	0.679
Hypertension, n (%)	28 (52.8)	12 (44.4)	0.478
Diabetes, n (%)	10 (18.9)	4 (14.8)	0.652
Smoking, n (%)	15 (28.3)	9 (33.3)	0.642
Drinking, n (%)	22 (41.5)	11 (40.7)	0.947
ICAM-1 (ng/mL)	244.14 ± 60.41	251.69 ± 59.50	0.597
VCAM-1 (ng/mL)	286.35 ± 63.82	283.87 ± 65.19	0.871
HAMD	22.92 ± 3.30	13.07 ± 3.41	< 0.001
MMSE	24.62 ± 2.96	27.52 ± 2.83	< 0.001
MoCA-B	24.26 ± 2.77	26.04 ± 2.47	0.006
CRP (mg/L)	3.09 ± 4.61	2.26 ± 2.82	0.393

ICAM-1: Intercellular adhesion molecule-1; VCAM-1: Vascular cell adhesion molecule 1; HAMD: Hamilton depression scale; MMSE: Mini-mental state examination; MoCA-B: Montreal cognitive assessment basic; CRP: C-reactive protein.