Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis

Table 1 Characteristics of studies included in the study

First author	Year	Country	Population	Diagnostic criteria	Age (mean ± SD) (years)	Sample size (man/female)	Efficacy criteria	Treatment duration (weeks)	Antidepressant medication
Ramesh	2022	India	Asian	DSM-IV	39.26 ± 11.52	125 (73/52)	HAMD	8	SER, ESC, FLU, PAR
Scutt	2018	United Kingdom	Caucasian	DSM-IV	88.16 ± 3.80	19 (5/14)	Geriatric depression scale	4	CIT
Basu	2015	India	Asian	DSM-IV	35.0 ± 10.3	55 (32/23)	MADRS	6-8	ESC
Chang	2014	South Korea	Asian	DSM-IV	NA	283 (254/290)	HAMD-17	12	Mirtazapine
Serretti	2013	Italy	Caucasian	DSM-IV	43.93 ± 15.93	117 (80/37)	Hamilton depression rating scale	8	AD
Zhao	2012	China	Asian	DSM-IV	45.75 ± 7.28	85 (28/57)	HAMD-21	4	SER
Noro	2010	Belgium, Austria, Israel	Caucasian	DSM-IV	NA	206	HAMD-17	4	AD
Illi	2009	Finland	Caucasian	DSM-IV	44.4 ± 13.9	86	MADRS	6	FLU, PAR, CIT
Kato	2009	Japan	Asian	DSM-IV	45.8 ± 14.4	137 (75/62)	HAMD	6	Selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors
Lin	2009	China	Asian	DSM-IV	38.4 ± 12.6	101 (26/75)	HAMD	≥ 2	Venlafaxine, SER, PAR, FLU
Serretti	2004	Italy	Caucasian	DSM-IV	NA	262 (173/89)	HAMD-21	6	Fluvoxamine

DSM-IV: Diagnostic and statistical manual of mental disorders, fourth edition; MADRS: Montgomery and asberg depression rating scale; HAMD: Hamilton depression scale; ESC: Escitalopram; FLU: Fluoxetine; PAR: Paroxetine; SER: Sertraline; NA: Not available; AD: Antidepressant drug; CIT: Citalopram.