Association between inflammatory bowel disease and all-cause dementia: A two-sample Mendelian randomization study

doi:10.5498/wjp.v14.i1.15

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World Journal of Psychiatry

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Psychiatry. Jan 19, 2024; 14(1): 15-25
Published online Jan 19, 2024. doi: 10.5498/wjp.v14.i1.15

Table 1 Details of the genome-wide association studies included in the Mendelian randomization

Phenotype	Consortium	Year	Ncase	Ncontrol	Population
IBD	IIBDGC	2015	12882	21770	European
UC	IIBDGC	2015	6968	20464	European
CD	IIBDGC	2015	5956	14927	European
IBD (val)	United Kingdom Biobank	2021	7045	449282	United Kingdom
All-cause dementia	FinnGen	2022	11602	294500	Finnish
Dementia in AD	FinnGen	2022	3540	294500	Finnish
VaD	FinnGen	2022	1602	297552	Finnish
Dementia in other diseases classified elsewhere	FinnGen	2022	882	294500	Finnish
Unspecified dementia	FinnGen	2022	2729	294500	Finnish

IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn’s disease; AD: Alzheimer’s disease; VaD: Vascular dementia; IIBDGC: International Inflammatory Bowel Disease Genetics Consortium.

Citation: Liao OL, Xie SY, Ye J, Du Q, Lou GC. Association between inflammatory bowel disease and all-cause dementia: A two-sample Mendelian randomization study. World J Psychiatry 2024; 14(1): 15-25
URL: https://www.wjgnet.com/2220-3206/full/v14/i1/15.htm
DOI: https://dx.doi.org/10.5498/wjp.v14.i1.15