Glutamate decarboxylase 1 gene polymorphisms are associated with respiratory symptoms in panic disorder

doi:10.5498/wjp.v13.i7.435

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World Journal of Psychiatry

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World J Psychiatry. Jul 19, 2023; 13(7): 435-443
Published online Jul 19, 2023. doi: 10.5498/wjp.v13.i7.435

Table 2 Glutamate decarboxylase 1 gene polymorphisms of patients with panic disorder vs controls in the Chinese population, n (%)

SNP	Alleles and genotypes	PD (n = 230)	Controls (n = 224)	Model	OR (95%CI)	P value
rs1978340	A	122 (26.5)	116 (25.9)	Allele^a	1.003 (0.769-1.389)	0.829
	G	338 (73.5)	332 (74.1)	Allele^a	1.003 (0.769-1.389)	0.829
	A/A	17 (7.4)	20 (8.9)	Additive^b	1.031 (0.774-1.373)	0.835
	A/G	88 (38.3)	76 (34.8)	Dominant^b	1.120 (0.773-1.622)	0.549
	G/G	125 (54.3)	128 (57.1)	Recessive^b	0.814 (0.415-1.598)	0.550
rs3749034	A	131 (28.5)	129 (28.8)	Allele	0.985 (0.738-1.313)	0.916
	G	329 (71.5)	319 (71.2)	Allele	0.985 (0.738-1.313)	0.916
	A/A	17 (7.4)	15 (6.7)	Additive	0.984 (0.732-1.323)	0.914
	A/G	97 (42.2)	99 (44.2)	Dominant	0.948 (0.656-1.370)	0.777
	G/G	116 (50.4)	110 (49.1)	Recessive	1.112 (0.541-2.286)	0.773

^aChi-square test.

^bLogistic regression analyses.

OR: Odds ratios; CI: Confidence interval; SNP: Single Nucleotide Polymorphism, “A” represent wild type and “a” represent mutant type: allele, a vs A; additive, aa vs Aa vs AA; dominant, aa + Aa vs AA, recessive, aa vs Aa +AA; PD: Panic disorder.

Citation: Zou ZL, Qiu J, Zhou XB, Huang YL, Wang JY, Zhou B, Zhang Y. Glutamate decarboxylase 1 gene polymorphisms are associated with respiratory symptoms in panic disorder. World J Psychiatry 2023; 13(7): 435-443
URL: https://www.wjgnet.com/2220-3206/full/v13/i7/435.htm
DOI: https://dx.doi.org/10.5498/wjp.v13.i7.435