Copyright
©The Author(s) 2023.
World J Psychiatry. Apr 19, 2023; 13(4): 141-148
Published online Apr 19, 2023. doi: 10.5498/wjp.v13.i4.141
Published online Apr 19, 2023. doi: 10.5498/wjp.v13.i4.141
Figure 3 Schematic representation of the proposed role of the kynurenine pathway in the pathophysiology of major depressive disorder.
Mutual interactions between serotonergic and glutamatergic functions are indicated by the bidirectional arrows for increased or decreased function. MDD: Major depressive disorder; KMO: Kynurenine monooxygenase; Trp: Tryptophan; IDO: Indoleamine 2,3-dioxygenase; TDO: Tryptophan 2,3-dioxygenase; IFN: Interferon; IL: Interleukin.
- Citation: Badawy AAB, Dawood S, Bano S. Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder. World J Psychiatry 2023; 13(4): 141-148
- URL: https://www.wjgnet.com/2220-3206/full/v13/i4/141.htm
- DOI: https://dx.doi.org/10.5498/wjp.v13.i4.141