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©The Author(s) 2023.
World J Psychiatry. Feb 19, 2023; 13(2): 75-83
Published online Feb 19, 2023. doi: 10.5498/wjp.v13.i2.75
Published online Feb 19, 2023. doi: 10.5498/wjp.v13.i2.75
Table 2 mtDNA mutations in two Chinese pedigrees with major depressive disorder
Gene | Positon | Replacement | Conservationa (H/B/M/X) | CRSb | NB011 | NB054 | Previously reportedc |
D-loop | 73 | A-G | A | G | G | Y | |
146 | T-C | T | C | C | Y | ||
153 | A-G | A | G | G | Y | ||
263 | A-G | A | G | G | Y | ||
309 | C-CCT | C | CCT | Y | |||
310 | T-C | T | TC | C | Y | ||
489 | T-C | T | C | C | Y | ||
16223 | C-T | C | T | T | Y | ||
16234 | C-T | C | T | T | Y | ||
16291 | C-T | C | T | Y | |||
16316 | A-G | A | G | G | Y | ||
16362 | T-C | T | C | C | Y | ||
12S rRNA | 750 | A-G | A/A/A/- | A | G | G | Y |
1041 | A-G | A/T/T/T | A | G | G | Y | |
1438 | A-G | A/A/A/G | A | G | G | Y | |
16S rRNA | 2706 | A-G | A/G/A/A | A | G | G | Y |
ND1 | 3394 | T-C (Tyr30His) | Y/Y/Y/Y | T | C | C | Y |
4216 | T-C (Tyr304His) | Y/H/H/H | T | C | Y | ||
ND2 | 4491 | G-A (Val8Ile) | V/I/I/V | G | A | A | Y |
4769 | A-G | A | G | G | Y | ||
CO1 | 7028 | C-T | C | T | T | Y | |
7142 | T-C | T | C | Y | |||
CO2 | 7861 | T-C | T | C | Y | ||
ATP6 | 8701 | A-G (Thr59Ala) | T/S/L/Q | A | G | G | Y |
8728 | TG-T (Trp68Gly) | W/W/W/W | TG | T | N | ||
8860 | A-G (Thr112Ala) | T/A/A/T | A | G | G | Y | |
9136 | A-G (Ile204Val) | I/F/F/I | A | G | N | ||
CO3 | 9242 | A-G | A | G | Y | ||
9540 | T-C | T | C | C | Y | ||
ND3 | 10398 | A-G (Thr114Ala) | T/T/T/A | A | G | G | Y |
10400 | C-T | C | T | T | Y | ||
ND4 | 10873 | T-C | T | C | C | Y | |
11719 | G-A | G | A | A | Y | ||
ND5 | 12705 | C-T | C | T | T | Y | |
ND6 | 14308 | T-C | T | C | C | Y | |
14417 | A-G (Val86Ala) | V/K/W/S | A | G | Y | ||
CYTB | 14766 | C-T (Thr7Ile) | T/S/T/S | C | T | T | Y |
14783 | T-C | T | C | C | Y | ||
15043 | G-A | G | A | A | Y | ||
15301 | G-A | G | A | A | Y | ||
15326 | A-G (Thr194Ala) | T/M/I/I | A | G | G | Y |
- Citation: Jing P, Mei X, Zhang YY, Zheng FJ, Luo XM, Liu LJ, Yu HH, Zhang XB. Major depressive disorder is correlated with the mitochondrial ND1 T3394C mutation in two Han Chinese families: Two case reports. World J Psychiatry 2023; 13(2): 75-83
- URL: https://www.wjgnet.com/2220-3206/full/v13/i2/75.htm
- DOI: https://dx.doi.org/10.5498/wjp.v13.i2.75