Major depressive disorder is correlated with the mitochondrial ND1 T3394C mutation in two Han Chinese families: Two case reports

Table 2 mtDNA mutations in two Chinese pedigrees with major depressive disorder

Gene	Positon	Replacement	Conservationa (H/B/M/X)	CRSb	NB011	NB054	Previously reportedc
D-loop	73	A-G		A	G	G	Y
	146	T-C		T	C	C	Y
	153	A-G		A	G	G	Y
	263	A-G		A	G	G	Y
	309	C-CCT		C		CCT	Y
	310	T-C		T	TC	C	Y
	489	T-C		T	C	C	Y
	16223	C-T		C	T	T	Y
	16234	C-T		C	T	T	Y
	16291	C-T		C	T		Y
	16316	A-G		A	G	G	Y
	16362	T-C		T	C	C	Y
12S rRNA	750	A-G	A/A/A/-	A	G	G	Y
	1041	A-G	A/T/T/T	A	G	G	Y
	1438	A-G	A/A/A/G	A	G	G	Y
16S rRNA	2706	A-G	A/G/A/A	A	G	G	Y
ND1	3394	T-C (Tyr30His)	Y/Y/Y/Y	T	C	C	Y
	4216	T-C (Tyr304His)	Y/H/H/H	T	C		Y
ND2	4491	G-A (Val8Ile)	V/I/I/V	G	A	A	Y
	4769	A-G		A	G	G	Y
CO1	7028	C-T		C	T	T	Y
	7142	T-C		T	C		Y
CO2	7861	T-C		T	C		Y
ATP6	8701	A-G (Thr59Ala)	T/S/L/Q	A	G	G	Y
	8728	TG-T (Trp68Gly)	W/W/W/W	TG		T	N
	8860	A-G (Thr112Ala)	T/A/A/T	A	G	G	Y
	9136	A-G (Ile204Val)	I/F/F/I	A		G	N
CO3	9242	A-G		A	G		Y
	9540	T-C		T	C	C	Y
ND3	10398	A-G (Thr114Ala)	T/T/T/A	A	G	G	Y
	10400	C-T		C	T	T	Y
ND4	10873	T-C		T	C	C	Y
	11719	G-A		G	A	A	Y
ND5	12705	C-T		C	T	T	Y
ND6	14308	T-C		T	C	C	Y
	14417	A-G (Val86Ala)	V/K/W/S	A	G		Y
CYTB	14766	C-T (Thr7Ile)	T/S/T/S	C	T	T	Y
	14783	T-C		T	C	C	Y
	15043	G-A		G	A	A	Y
	15301	G-A		G	A	A	Y
	15326	A-G (Thr194Ala)	T/M/I/I	A	G	G	Y

^aConservation of amino acids for polypeptides or nucleotides for RNAs in human, bovine, mouse, and Xenopus laevis.

^bCambridge reference sequence (Andrews et al[14], 1999).

^cSee online mitochondrial genome databases http://www.mitomap.org and http://www.genpat.uu.se/mtDB/.

CRS: Cambridge reference sequence; H: Human; B: Bovine; M: Mouse; X: Xenopus laevis.