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©The Author(s) 2022.
World J Psychiatry. Sep 19, 2022; 12(9): 1150-1168
Published online Sep 19, 2022. doi: 10.5498/wjp.v12.i9.1150
Published online Sep 19, 2022. doi: 10.5498/wjp.v12.i9.1150
Table 2 Histone tail modifications studies on depressed suicide victims
Gene (region)/histone tail modification | Alteration | Subjects and collected tissue | Ref. |
BDNF, H3K9/14ac, H3K27me2 | ↓ H3K9/14ac, ↑ HDAC2, ↑ HDAC3, ↑ H3K27me2, ↓ BDNF in HPC and NAc. ↑ Sin3a in HPC | 14 suicide victims (5 females and 9 males) without psychiatric diagnosis and 8 controls (3 females and 5 males). Brain tissue (HPC, NAc, and FCx; BA10) | Misztak et al[53], 2020 |
H3K4me3 | ↑ In H3K4me3 at promoter of SYN2. ↑ expression SYN2b; no changes in SYN2a expression | 7 females and 11 males with MDD suicide victims and 14 controls (3 females and 12 males). Brain tissue (PFC; BA10) | Cruceanu et al[81], 2013 |
H3K14ac | ↑ H3K14ac. ↓ HDAC2 mRNA expression | 8 depressed females and males. Brain tissue (NAc) | Covington et al[11], 2009 |
- Citation: Šalamon Arčan I, Kouter K, Videtič Paska A. Depressive disorder and antidepressants from an epigenetic point of view. World J Psychiatry 2022; 12(9): 1150-1168
- URL: https://www.wjgnet.com/2220-3206/full/v12/i9/1150.htm
- DOI: https://dx.doi.org/10.5498/wjp.v12.i9.1150