ABCB9 polymorphism rs61955196 is associated with schizophrenia in a Chinese Han population

doi:10.5498/wjp.v12.i7.904

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World Journal of Psychiatry

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World J Psychiatry. Jul 19, 2022; 12(7): 904-914
Published online Jul 19, 2022. doi: 10.5498/wjp.v12.i7.904

Table 1 Association analysis for four target single-nucleotide polymorphisms and schizophrenia risk, n (%)¹

SNP	Genotype/allele	SCZ (n = 443)	HC (n = 511)	P value	OR (95%CI)	HWE test for controls
rs11917047 (PTPRG)	AA	219 (49.4)	259 (50.7)		1.00 (ref)	0.151
	AG	183 (41.3)	200 (39.1)	0.431	1.12 (0.85-1.47)
	GG	41 (9.3)	52 (10.2)	0.713	0.92 (0.58-1.45)
	A	621 (70.1)	718 (70.3)		1.00 (ref)
	G	265 (29.9)	304 (29.7)	0.885	1.02 (0.83-1.24)
rs2239681 (IGF2)	AA	156 (35.2)	177 (34.6)		1.00 (ref)	0.104
	AG	211 (47.6)	232 (45.4)	0.667	1.07 (0.80-1.43)
	GG	76 (17.2)	102 (20.0)	0.447	0.87 (0.59-1.26)
	A	523 (59.0)	586 (57.3)		1.00 (ref)
	G	363 (41.0)	436 (42.7)	0.567	0.95 (0.79-1.14)
rs3842756 (INSIGF)	CC	405 (91.4)	475 (93.0)		1.00 (ref)	0.409
	CT	38 (8.6)	36 (7.0)	0.319	1.28 (0.79-2.08)
	TT	-	-	-	-
	C	848 (95.7)	986 (96.5)		1.00 (ref)
	T	38 (4.3)	36 (3.5)	0.329	1.27 (0.79-2.04)
rs61955196 (ABCB9)	CC	157 (35.4)	202 (39.5)		1.00 (ref)	0.513
	CG	213 (48.1)	244 (47.7)	0.297	1.16 (0.88-1.55)
	GG	73 (16.5)	65 (12.7)	0.037^a	1.54 (1.03-2.30)
	C	527 (59.5)	648 (63.4)		1.00 (ref)
	G	359 (40.5)	374 (36.6)	0.042^a	1.22 (1.01-1.47)

^aP < 0.05.

¹Adjusted for gender.

SCZ: Schizophrenia; HC: Healthy control; OR: Odds ratio; HWE: Hardy-Weinberg equilibrium; SNP: Single-nucleotide polymorphism.

Citation: Li XW, Zhang MY, Li ZJ, Ai LZ, Jin MD, Jia NN, Xie MT, Yang YQ, Li WZ, Dong L, Yu Q. ABCB9 polymorphism rs61955196 is associated with schizophrenia in a Chinese Han population. World J Psychiatry 2022; 12(7): 904-914
URL: https://www.wjgnet.com/2220-3206/full/v12/i7/904.htm
DOI: https://dx.doi.org/10.5498/wjp.v12.i7.904