Disrupted leptin-fatty acid biosynthesis is an early manifestation of metabolic abnormalities in schizophrenia

Figure 4 Association of plasma leptin with erythrocyte saturated fatty acids and body mass index. A-D: In first-episode psychosis patients, plasma leptin showed negative correlation with saturated fatty acids (SFAs)-palmitic acid (PA) (A, r = −0.4335, P = 0.0194) but not with body mass index (BMI) (B, r = 0.2169, P = 0.3206), whereas, in chronic schizophrenia patients, plasma leptin showed positive correlation with BMI (C, r = 0.4135, P = 0.0152) but not with erythrocyte SFAs-PA (D, r = 0.3331, P = 0.1401). FEP: First-episode psychosis; CSZ: Chronic schizophrenia; BMI: Body mass index; SFAs: Saturated fatty acids; PA: Palmitic acid.