Disrupted leptin-fatty acid biosynthesis is an early manifestation of metabolic abnormalities in schizophrenia

Figure 2 Association of plasma leptin with clinical symptom (positive and negative syndrome scale) scores. A and B: In first-episode psychosis patients, plasma leptin showed negative correlation with both positive symptom score (PANSS-PSS) (r = −0.4034, P = 0.028) and negative symptom score (PANSS-NSS) (r = −0.3487, P = 0.05); C and D: In chronic schizophrenia patients, no significant negative correlation was observed between plasma leptin and either PANSS-PSS (r = −0.3055, P = 0.18) or PANSS-NSS (r = −0.3001; P = 0.13). PANSS-PSS: Positive and negative syndrome scale-positive symptom score; PANSS-NSS: Positive and negative syndrome scale-negative symptom score; FEP: First-episode psychosis; CSZ: Chronic schizophrenia.