Altered thalamic subregion functional networks in patients with treatment-resistant schizophrenia

Table 3 Comparison of functional connectivity of thalamic subregions with cortical voxels between patients with treatment-resistant schizophrenia (n = 50) and healthy controls (n = 61)

Seed Region	MNIcoordinate	Cluster Size	t value	P FWE	P-unc	Name (voxel size - region)
TRS > HCs
Thalamic subregion 1	-14 -44 -12	612	5.22	0.009	< 0.001	339 - Left lingual gyrus142 - Left cerebellum 4_5
Thalamic subregion 2	-28 -10 66	1309	5.30	< 0.001	< 0.001	604 - Left precentral gyrus483 - Left postcentral gyrus
Thalamic subregion 3	10 6 54	523	5.26	0.003	< 0.001	173 - Right supplementary motor cortex
Thalamic subregion 6	-8 38 -22	1229	7.05	< 0.001	< 0.001	186 - Frontal medial cortex
	-36 -34 62	358	5.26	0.030	< 0.001	342 - Left postcentral gyrus
	26 -28 60	467	4.79	0.006	< 0.001	305 - Right precentral gyrus132 - Right postcentral gyrus
Thalamic subregion 9	-44 -14 42	380	5.26	0.020	< 0.001	281 - Left precentral gyrus
TRS < HCs
Thalamic subregion 3	6 -90 -2	458	-4.18	0.008	< 0.001	163 - Left intracalcarine cortex

Thresholded at P < 0.01, uncorrected; P < 0.05, Family Wise Error rate corrected. TRS: Treatment-resistant schizophrenia; HCs: Healthy controls.