Altered thalamic subregion functional networks in patients with treatment-resistant schizophrenia

Table 2 Comparison of between- and within-functional connectivity of thalamic subregions and cortical functional networks between patients with treatment-resistant schizophrenia (n = 50) and HCs (n = 61)

Seed region	t value	P FWE	P-unc	Brain region
TRS > HCs
Thalamic subregion 2	2.78	< 0.001	0.006	Medial occipital network
Cingulo-opercular network	3.29	0.008	0.001	Medial occipital network
	2.63	0.008	0.010	Superior fronto-parietal network
Medial temporal network	4.31	< 0.001	< 0.001	Superior fronto-parietal network
TRS < HCs
Thalamic subregion 1	-4.58	< 0.001	< 0.001	Thalamic subregion 2
	-2.95	0.019	0.004	Thalamic subregion 9
Thalamic subregion 2	-3.16	< 0.001	0.002	Thalamic subregion 3
	-3.38	< 0.001	0.001	Thalamic subregion 4
Fronto-parietal network	-2.69	< 0.001	0.008	Medial temporal network
	-2.73	0.008	0.007	Superior fronto-parietal network
Default mode network	-2.90	< 0.001	0.004	Cingulo-opercular network
	-3.37	< 0.001	0.001	Medial occipital network
	-5.40	< 0.001	< 0.001	Medial temporal network

Thresholded at P < 0.01, uncorrected; P < 0.05, Family Wise Error rate corrected. TRS: Treatment-resistant schizophrenia; HCs: Healthy controls.