Minireviews
Copyright ©The Author(s) 2022.
World J Psychiatry. Apr 19, 2022; 12(4): 588-602
Published online Apr 19, 2022. doi: 10.5498/wjp.v12.i4.588
Table 2 Attribution of serendipity in the discovery of classical antidepressant drugs
Group/Family
Drug
ATC code
Date of discovery (psychiatric introduction)
Effect/primary properties1
Effect/secondary properties2
Pattern of discovery
TCAsImipramineN06AA021951 (1957)SNSII
AmitriptylineN06AA091958 (1961)NSNSIV
TrimipramineN06AA061964 (1966)NSNSIV
ButriptylineN06AA151964NSNSIV
DesipramineN06AA011964NSNSIV
ClomipramineN06AA041963 (1970)NSNSIV
NortriptylineN06AA101963 (1967)NSNSIV
ProtriptylineN06AA111967NSNSIV
IprindoleN06AA131967NSNSIV
DoxepinN06AA121969NSNSIV
DibenzepinN06AA081970NSNSIV
Maprotiline3N06AA211967 (1973)NSNSIV
DosulepinN06AA161977NSNSIV
AmineptineN06AA191978NSNSIV
AmoxapineN06AA171980NSNSIV
QuinupramineN06AA231983NSNSIV
LofepramineN06AA071989NSNSIV
MAOIIproniazidN06AF051952 (1957)SNSII
IsocarboxazidN06AF011959NSNSIV
PhenelzineN06AF031960NSNSIV
TranylcypromineN06AF041961NSNSIV
NialamideN06AF021988NSNSIV
OCATrazodoneN06AX051966 (1973)NSNSIV
NomifensineN06AX041977NSNSIV
MianserinN06AX031966 (1979)SNSII