Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model

Figure 6 Magnesium-L-threonate treatment prevented the upregulation of amyloid β_1-42, hypoxia-inducible factor-1α and NADPH oxidase 4 proteins in APPswe/PS1dE9 mouse hippocampus. A: Protein band images of hypoxia-inducible factor (HIF)-1α, NADPH oxidase (NOX) 4, amyloid β (Aβ)_1-42 and glyceraldehyde-3-phosphate dehydrogenase of each group; B: The HIF-1α protein expression of each group; C: The NOX4 protein expression of each group; D: The Aβ_1-42 protein expression of each group. n = 3. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs former group. MgT: Magnesium-L-threonate; TG: APPswe/PS1dE9 mice group; WT: Wild-type mice group; Aβ: Amyloid β; HIF: hypoxia-inducible factor; NOX: NADPH oxidase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.