Insights into myelin dysfunction in schizophrenia and bipolar disorder

Figure 1 Myelin in the central nervous system. Left, a schematic representation of central nervous system (CNS) cells and their multidirectional interactions. Right, the main protein and lipid components of CNS myelin. Proteomic studies have revealed altered expression of myelin proteins in postmortem brain samples from patients with schizophrenia or bipolar disorder. MBP: Myelin basic protein; CNP: 2’,3’-cyclic nucleotide 3’-phosphodiesterase; PLP: Proteolipid protein; MOG: Myelin-oligodendrocyte glycoprotein; MAG: Myelin-associated glycoprotein.