Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression, anxiety and psychosis

Table 5 Results of multiple regression analysis with rating scales as dependent variables and paraoxonase status as explanatory variables

Dependent variables	Explanatory variables (model)	β	t value	P value	F model	Df	P value	Partial Eta squared
BPRS	CMPAase	-0.444	-6.09	< 0.001	29.35	2/143	< 0.001	0.291
	Education	-0.213	-2.93	0.004
Psychosis	CMPAase	-0.260	-3.20	0.002	9.56	2/143	< 0.001	0.118
	Education	-0.167	-2.06	0.041
Negative symptoms	Education	-0.329	-4.52	< 0.001	12.75	4/141	< 0.001	0.226
	Sex	-0.329	-4.29	< 0.001
	Res CMPAase	-0.189	-2.56	< 0.011
	Age	-0.172	-2.30	0.023
HAM-D	CMPAase	-0.347	-4.51	< 0.001	11.95	4/140	< 0.001	0.254
	Education	-0.231	-3.02	0.003
	Overdominant model	-0.227	-3.06	0.003
	Sex	0.170	2.31	0.023
Suicidal ideation	Dominant model	0.354	4.61	< 0.001	13.21	2/143	< 0.001	0.156
	Res CMPAase	-0.173	-2.26	0.025
Physiosomatic symptoms	CMPAase	-0.349	-4.47	< 0.001	19.94	1/144	< 0.001	0.122
PMR	Education	-0.386	-5.13	< 0.001	14.75	4/141	< 0.001	0.295
	Sex	-0.252	-3.54	0.001
	Res CMPAase	-0.243	-3.36	0.001
	Age	-0.186	-2.53	0.013
HAM-A	CMPAase	-0.350	-4.80	< 0.001	12.93	2/143	< 0.001	0.153
	Sex	0.163	2.10	0.037
Psychopathology index	CMPAase	-0.430	-5.83	< 0.001	19.94	3/141	< 0.001	0.298
	Education	-0.250	-3.41	0.002
	Overdominant model	-0.148	-2.07	0.040
MMSE	Education	0.593	9.09	< 0.001	54.48	2/142	< 0.001	0.434
	CMPAase	0.175	2.69	0.008

BPRS: Brief Psychiatric Rating Scale; HAM-D: Hamilton Depression Rating Scale; HAM-A: Hamilton Anxiety Rating Scale; MMSE: Mini Mental State Examination; PMR: Psychomotor retardation; Res CMPAase: Residualized (after regression on PON1 genotype); CMPAase: 4-(chloromethyl)phenyl acetate hydrolysis; Dominant and overdominant model: PON1 Q192R genotype models.