Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression, anxiety and psychosis

Table 3 Model-generated estimated marginal means of paraoxonase 1 levels in healthy controls and patients with temporal lobe epilepsy and psychosis, depression and anxiety due to temporal lobe epilepsy

Variables	HC1	TLE2	TLE + PSY3	TLE + DEP4	TLE + ANX5
CMPAase (U/mL)	42.1 (1.3)2,3,4,5	28.5 (1.6)1	24.5 (1.6)1	24.8 (1.7)1	27.3 (1.7)1
Res CMPAase (z scores)	1.041 (0.128)2,3,4,5	-0.196 (0.150)1	-0.545 (0.163)1	-0.545 (0.163)1	-0.375 (0.159)1
Arylesterase (U/mL)	212.4 (9.0)2,3,4,5	156.4 (10.5)1	144.2 (10.4)1	143.7 (11.4)1	137.3 (11.2)1
Res Arylesterase (z scores)	0.920 (0.140)2,3,4,5	-0.193 (0.163)1	-0.425 (0.162)1	-0.400 (0.177)1	-0.434 (0.174)1

^1-5Results of post-hoc comparisons among the five diagnostic groups.

¹Indicates HC and “1” associated with column figures indicates that this value is different from HC.

²Indicates TLE and “2” associated with column figures indicates that this value is different from TLE.

³Indicates TLE + PSY and “3” associated with column figures indicates that this value is different from TLE + PSY.

⁴Indicates TLE + DEP and “4” associated with column figures indicates that this value is different from TLE + DEP.

⁵Indicates TLE + ANX and “5” associated with column figures indicates that this value is different from TLE + ANX.

TLE: Temporal lobe epilepsy; TLE: TLE without psychiatric comorbidities; TLE + PSY: Psychotic Disorder due to TLE; TLE + DEP: Mood Disorder due to TLE with depressive features; TLE + ANX: Anxiety Disorder due to TLE; HC: Healthy controls; PON1: Paraoxonase; CMPAase: 4-(chloromethyl)phenyl acetate hydrolysis; Res: Residualized values after regression on PON1 genotype.