Review
Copyright ©The Author(s) 2022.
World J Psychiatry. Jan 19, 2022; 12(1): 77-97
Published online Jan 19, 2022. doi: 10.5498/wjp.v12.i1.77
Figure 4
Figure 4 Brain-derived neurotrophic factor deficiency impairs resolution of microglial inflammatory phenotypes. Brain-derived neurotrophic factor (BDNF) levels are altered by genetics and environmental circumstances. Reduced levels of BDNF impair microglia regulation after inflammation. Hyper-active microglia contribute to blood-brain barrier disruption and express higher levels of pro-inflammatory cytokines and kynurenine metabolism pathway enzymes. Individuals with hyper-active microglia are vulnerable to developing symptoms of depression after inflammatory challenge. BDNF: Brain-derived neurotrophic factor.