Review
Copyright ©The Author(s) 2022.
World J Psychiatry. Jan 19, 2022; 12(1): 77-97
Published online Jan 19, 2022. doi: 10.5498/wjp.v12.i1.77
Figure 2
Figure 2 Hypothesis diagram. Brain-derived neurotrophic factor (BDNF) deficiency and elevated or chronic neuroinflammation independently confer vulnerability to development of major depressive disorder. BDNF plays a negative regulatory role in resolving neuroinflammation, and high inflammation reduces BDNF expression. BDNF: Brain-derived neurotrophic factor. BDNF: Brain-derived neurotrophic factor.