Selective ablation of type 3 adenylyl cyclase in somatostatin-positive interneurons produces anxiety- and depression-like behaviors in mice

Figure 4 Somatostatin-Cre recombinase:type 3 adenylyl cyclase^f/f mice showed depression-like behavior. A and B: Somatostatin-Cre recombinase (SST-Cre):type 3 adenylyl cyclase (AC3)^f/f mice showed increased immobile duration in forced swimming test (A) and more freezing time in tail suspension test (B). Bars represent the mean ± standard error of the mean. Data were analyzed using one-way analysis of variance followed by post hoc Tukey’s multiple comparisons test. n = 12 for AC3^flox/flox group, n = 8 for SST-Cre group, n = 15 for SST-Cre:AC3^f/f group. ^fP < 0.001 vs AC3^flox/flox. ^gP < 0.05 vs SST-Cre. .