Selective ablation of type 3 adenylyl cyclase in somatostatin-positive interneurons produces anxiety- and depression-like behaviors in mice

Figure 2 Type 3 adenylyl cyclase^flox/flox mice exhibit normal emotion-related behaviors and motor ability compared with wild-type C57 mice. A and B: Anxiety-related behavioral tests were illustrated by the open field test (A) and elevated plus maze (B); C and D: Depression-like behavioral tests were examined by the forced swimming test (C) and tail suspension test (D); E: Motor ability was examined by the rotarod test. Bars represent the mean ± standard error of the mean. Data were analyzed using the Student’s t-test. n = 7 for the wild-type (WT) group, n = 8 for the type 3 adenylyl cyclase (AC3)^flox/flox group.