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©The Author(s) 2021.
World J Psychiatr. Nov 19, 2021; 11(11): 1116-1128
Published online Nov 19, 2021. doi: 10.5498/wjp.v11.i11.1116
Published online Nov 19, 2021. doi: 10.5498/wjp.v11.i11.1116
Table 1 Univariate comparisons of demographic and clinical features by empirically-derived clusters (n = 105), mean ± SD
Total | Simple pharmacy, | Simple pharmacy, | Complex pharmacy, | Complex pharmacy, | P value for univariate omnibus test | |
Demographic and general clinical data | ||||||
Age (yr) | 51.5 (13.2) | 42.6 (14.4) | 50.6 (15.2) | 54.9 (9.1) | 56.5 (10.3) | 0.02 |
Age of onset (yr) | 44.5 (13.6) | 36.3 (14.4) | 43.2 (15.3) | 48.6 (10.0) | 49.6 (11.0) | 0.01 |
Female, n (%) | 80 (75.5) | 15 (78.9) | 24 (72.7) | 27 (79.4) | 13 (68.4) | 0.79 |
Comorbid anxiety disorder, n (%) | 22 (20.8) | 6 (31.6) | 9 (27.3) | 4 (11.8) | 3 (15.8) | 0.25 |
Number of comorbid physical diseases | 0.7 (1.3) | 0.5 (1.2) | 0.7 (1.4) | 1.1 (1.5) | 0.6 (1.2) | 0.39 |
Follow-up duration after 2-yr of disease onset (yr) | 3.7 (3.5) | 3.2 (3.2) | 3.4 (3.1) | 3.7 (3.2) | 3.8 (3.9) | 0.91 |
Psychotropic loads | ||||||
Antidepressant load (defined daily dose/month) | 34.5 (18.4) | 13.3 (7.2) | 32.1 (13.1) | 42.8 (17.3) | 44.8 (17.7) | < 0.001 |
Sedative load (equivalent dose/month) | 57.3 (56.8) | 8.1 (10.8) | 18.5 (20.9) | 91.9 (45.4) | 112.0 (56.7) | < 0.001 |
Augmentation load (defined daily dose/month) | 1.2 (2.7) | 0.1 (0.5) | 0.3 (0.6) | 0.3 (1.0) | 5.3 (4.0) | < 0.001 |
Clinical feature within 2-yr of disease onset | ||||||
Number of antidepressants use | 1.7 (0.9) | 1.3 (0.6) | 1.6 (0.8) | 1.9 (1.1) | 1.9 (0.9) | 0.07 |
Number of antidepressants use with adequate dosage and duration | 1.5 (0.9) | 1.1 (0.5) | 1.3 (0.8) | 1.7 (1.2) | 1.8 (0.8) | 0.04 |
Visits of psychiatric outpatient service | 17.3 (10.7) | 10.6 (5.8) | 15.5 (5.1) | 20.2 (10.6) | 21.8 (17.1) | 0.002 |
Frequencies of psychiatric admission | 0.2 (0.5) | 0.1 (0.3) | 0.2 (0.4) | 0.1 (0.3) | 0.7 (0.8) | < 0.001 |
Clinical feature beyond 2-yr of disease onset | ||||||
Visits of psychiatric outpatient service | 31.1 (66.7) | 9.7 (10.3) | 20.2 (24.7) | 41.4 (91.6) | 42.6 (78.4) | 0.22 |
Frequencies of psychiatric admission | 0.8 (0.5) | 0.0 (0.0) | 0.1 (0.4) | 0.1 (0.7) | 0.0 (0.0) | 0.71 |
Severity of depression in the recruitment1 | 1.5 (0.9) | 0.6 (1.0) | 0.9 (1.2) | 1.2 (1.3) | 1.7 (1.2) | 0.02 |
- Citation: Chen HC, Hsu HH, Lu ML, Huang MC, Chen CH, Wu TH, Mao WC, Hsiao CK, Kuo PH. Subgrouping time-dependent prescribing patterns of first-onset major depressive episodes by psychotropics dissection. World J Psychiatr 2021; 11(11): 1116-1128
- URL: https://www.wjgnet.com/2220-3206/full/v11/i11/1116.htm
- DOI: https://dx.doi.org/10.5498/wjp.v11.i11.1116