‘Omics’ of suicidal behaviour: A path to personalised psychiatry

Table 2 Overview of epigenomic studies that have examined suicidal behaviour

Type of -omic	Tissue	Number of samples	Main results	Ref.
Agilent 400K promoter tiling microarrays	Dentate gyrus	46 suicide completers and 16 comparison subjects	Significantly differential methylation of 366 promoters in suicide victims (273 hypermethylated and 93 hypomethylated)	Labonté et al[35], 2013
Illumina Infinium Human Methylation 27 BeadChip	Orbitoprefrontal cortex	25 depressed suicide cases and 28 non-psychiatric sudden death controls	Significantly increased DNA methylation in suicide victims	Haghighi et al[36], 2014
Illumina Human Methylation 450 BeadChip	Prefrontal cortex	23 suicide and 35 non-suicide	Significant altered methylation at four CpGs (ATP8A1, SKA2, LOC153328 and KCNAB2 in suicide victims	Guintivano et al[37], 2014
Illumina Human Methylation 450 BeadChip	Prefrontal cortex	Six suicide, six non-suicide	Significantly decreased level of methylation in suicide victims	Schneider et al[38], 2015
Illumina 450 K Infinium microarray	Prefrontal cortex	22 suicide completers and 28 control subjects	Significantly differential methylation of 454 CpGs in suicide completers	Kozlenkov et al[47], 2017
Methylation binding domain-2 (MBD2) sequencing	Prefrontal cortex	22 suicide cases and 17 controls	Significantly decreased methylation in suicide victims, with 115 differentially methylated regions	Nagy et al[39], 2015
Reduced-representation bisulphite sequencing	Prefrontal cortex and hippocampus	Nine suicide victims and nine controls	Significantly decreased methylation of 63 and 2406 CpGs and increased methylation of 43 and 328 CpGs in prefrontal cortex and hippocampus, respectively	Kouter et al[40], 2019
Illumina Infinium Human Methylation 450K BeadChip	Prefrontal cortex	21 suicides and six non-suicides	Significant correlation of 22 CpGs with gene expression in suicide victims	Cabrera-Mendoza et al[41], 2020