‘Omics’ of suicidal behaviour: A path to personalised psychiatry

Table 1 Genome-wide association studies and completed suicide

Type of -omic	Tissue	Number of samples	Main results	Ref.
Illumina Infinium PsychArray platform v 1.0 (approximately 555000 markers)	Blood	216 suicide cases from extended families	SP110 (rs181058279), AGBL2 (rs76215382), SUCLA2 (rs121908538), APH1B (rs745918508)	Coon et al[25], 2020
llumina Omni1-Quad Beadchip (1014770 markers)	Not stated	577 suicide attempters and suicides, 1233 non-attempter psychiatric and healthy controls	SNPs in STK3, ADAMTS14, PSME2, and TBX20 genes	Galfalvy et al[26], 2015
Affimetrix GeneChip Mapping 50K Xba Array (58900 markers)	Brain tissue	68 suicides, 31 non-suicide deaths	58 SNPs in or near 19 known genes	Galfalvy et al[27], 2013
Illumina HumanOmniExpress (733202 markers) and HumanOmniExpressExome BeadChips (273000 markers)	Not stated	Approximately 746 suicides and 14049 non-suicide controls	No genome-wide significant SNP; GTF2IRD1 locus suggested as associated with age at completed suicide	Otsuka et al[28], 2019
Affymetrix United Kingdom BiLEVE Axiom (807411 markers) or the Affymetrix United Kingdom Biobank Axiom (825927 markers) arrays	Blood	> 500000 subjects of different suicide phenotypes and non-suicidal controls	Significant loci for suicidality on chromosomes 9 (ZCCHC7), 11 (CNTN5) and 13 (rs7989250); genetic correlations between suicidality and depression	Strawbridge et al[31], 2019
Illumina Infinium PsychArray platform (593260 markers), Illumina HumanOmniExpress (733202 markers) and HumanOmniExpressExome BeadChips (273000 markers)	Blood	3413 suicides, 14810 controls	Two genome-wide significant loci involving six SNPs: rs34399104, rs35518298, rs34053895, rs66828456, rs35502061, and rs35256367. Additional 52 variants (mapping to 22 genes) with nominal significance	Docherty et al[29], 2020