Comparison of three administration modes for establishing a zebrafish seizure model induced by N-Methyl-D-aspartic acid

Figure 4 Immersion of N-Methyl-D-aspartic acid causes persistent seizure-like behavior in zebrafish. Seizure activity scores and onset times following N-Methyl-D-aspartic acid (NMDA)-immersion (300 μmol/L and 500 μmol/L NMDA, 40 mg/L resveratrol + 500 μmol/L NMDA, and 3 mg/kg MK-801 + 500 μmol/L NMDA). A: The mean seizure scores (± SE) for each group plotted against time after NMDA immersion; B: The latency of seizure onset after NMDA immersion. Bars represent mean ± SE of the time lag to the onset of the first convulsion in each group. Data were analyzed using one-way ANOVA and t-test for the different groups (n = 6) (^aP < 0.05, ^bP < 0.01 vs control). NMDA: N-Methyl-D-aspartic acid; RES: Resveratrol; MK: MK-801.