Ocular drug delivery systems: An overview

Figure 5 Vitreal and retinal distribution of intravitreally administered. A: Polyethyleneimine/glycol chitosan heterogeneous nanoparticles; B: Human serum albumin/glycol chitosan heterogeneous nanoparticles; C: Human serum albumin/ hyaluronic acid heterogeneous nanoparticles 6 h post-injection. Red color = FPR-552 conjugated nanoparticles, blue color = DAPI staining of retinal cell nuclei. VH: Vitreous; RE: Retina; ILM: Inner limiting membrane; INL: Inner nuclear layer; ONL: Outer nuclear layer, respectively. All images were captured at × 10 magnification. Reproduced with permission from reference Koo et al[66].