Copyright
©The Author(s) 2016.
World J Med Genet. Aug 27, 2016; 6(3): 22-33
Published online Aug 27, 2016. doi: 10.5496/wjmg.v6.i3.22
Published online Aug 27, 2016. doi: 10.5496/wjmg.v6.i3.22
Figure 6 Proton sponge effect.
Conceptual image of how chitosan-DNA nanoparticles may escape from lysosomes once endocytosed. H+, Cl-, and H2O influx into the lysosome in order to maintain pH, charge, and osmolarity. This movement of molecules causes swelling of the lysosome, eventual bursting, and escape from lysosomal digestion[77].
- Citation: Patel BJ, Vignesh NK, Hortelano G. Chitosan DNA nanoparticles for oral gene delivery. World J Med Genet 2016; 6(3): 22-33
- URL: https://www.wjgnet.com/2220-3184/full/v6/i3/22.htm
- DOI: https://dx.doi.org/10.5496/wjmg.v6.i3.22