Chitosan DNA nanoparticles for oral gene delivery

Figure 4 Effect of gastrointestinal enzymes on chitosan-DNA nanoparticles. A: Various digestive enzymes are secreted throughout the gastrointestinal tract. The genetic material within chitosan nanoparticles is most threatened by pancreatic nucleases such as deoxyribonuclease and ribonuclease[34]; B: Conjugation of chitosan polymer with ethylenediaminetetraacetic acid through a covalent bond at the amino group[37].