Copyright
©The Author(s) 2016.
World J Med Genet. Aug 27, 2016; 6(3): 22-33
Published online Aug 27, 2016. doi: 10.5496/wjmg.v6.i3.22
Published online Aug 27, 2016. doi: 10.5496/wjmg.v6.i3.22
Figure 2 Effect of gastrointestinal pH on chitosan-DNA nanoparticles.
A: pH varies drastically throughout the human gastrointestinal tract from acidic stomach to slightly basic distal bowel[14,15]. This in turn influences how chitosan-DNA polymers behave intraluminally; B: The conceptual interaction between negatively charged DNA and positively charged chitosan that becomes protonated at acidic pHs. This allows chitosan-DNA nanoparticles to remain stable at lower pHs.
- Citation: Patel BJ, Vignesh NK, Hortelano G. Chitosan DNA nanoparticles for oral gene delivery. World J Med Genet 2016; 6(3): 22-33
- URL: https://www.wjgnet.com/2220-3184/full/v6/i3/22.htm
- DOI: https://dx.doi.org/10.5496/wjmg.v6.i3.22