Regression of cardiovascular remodeling in hypertension: Novel relevant mechanisms

Figure 4 Schematic view of the current renin angiotensin system and sites of possible therapeutic interventions in hypertension and cardiovascular remodeling. Letters in blue: Receptor agonists or enzyme activators; surrounded by interrupted lines: Enzyme/receptor inhibitors. AT1R: Angiotensin II receptor type 1; AT2R: Angiotensin II receptor type 2; ACE: Angiotensin converting enzyme I; ACE2: Angiotensin converting enzyme 2; MrgDR: Mas-related G protein–coupled receptor; NEP: Neutral endopeptidase; TOP: Thimet oligopeptidase; POP: Prolyl oligopeptidase; PCP: Prolyl carboxypeptidase. Adapted and modified from reference[146].