Hepatitis B virus genotype distribution and mutation patterns: Insights and clinical implications for hepatitis B virus positive patients

Figure 1 The ribbon diagram of hepatitis B virus reverse transcriptase shows the location of the major mutations that confer resistance to three drugs available Entecavir, Lamivudine, Tenofovir. The hepatitis B virus reverse transcriptase model structure was constructed and refined as previously reported. Citation: Kim KH, Kim ND, Seong BL. Discovery and development of anti-HBV agents and their resistance. Molecules 2010; 15: 5878-5908. Copyright © The Author(s) 2010. Published by MDPI[23].