Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Clin Urol. Nov 24, 2014; 3(3): 238-248
Published online Nov 24, 2014. doi: 10.5410/wjcu.v3.i3.238
Figure 4
Figure 4 MiR-100 and miR-21 in high-grade invasive urothelial carcinoma carcinogenesis. High levels of miR-100 inhibit retinoblastoma (RB1) and over-expression of miR-21 suppresses p53 and phosphatase and tensin homolog gene (PTEN), three crucial protective genes. Inactivity of RB1 associated with loss of function of p53 and PTEN trigger high-grade urothelial carcinoma (UC) carcinogenesis. Adapted by Wu[19], 2009.