Ocular renin-angiotensin system with special reference in the anterior part of the eye

Figure 1 The renin-angiotensin system. The two main pathways of RAS: Ang II-ACE1-AT1R (blue lines) and Ang(1-7)-ACE2-MasR (red lines) are highlighted with colours. ACE(1): Angiotensin-converting enzyme (1); ACE2: Angiotensin-converting enzyme related carboxypeptidase; Ang I, II, III, IV: Angiotensin I, II, III, IV; Ang(1-10): Angiotensin (1-10); Ang(1-8): Angiotensin (1-8); Ang(2-8): Angiotensin (2-8); Ang(3-8): Angiotensin (3-8); Ang(1-9): Angiotensin (1-9); Ang(1-7): Angiotensin (1-7); Ang(1-5): Angiotensin (1-5); Ang(1-4): Angiotensin (1-4); Ang(2-7): Angiotensin (2-7); Ang(3-7): Angiotensin (3-7); Ang(3-4): Angiotensin (3-4); Ang(1-12): Angiotensin (1-12); Ang(5-8): Angiotensin (5-8); Ang(5-7): Angiotensin (5-7); Ang(2-10): Angiotensin (2-10); Ang A: Angiotensin A; AT1R: Angiotensin II type 1 receptor; AT2R: Angiotensin II type 2 receptor; AT4R: Angiotensin II type 4 receptor; AP: Aminopeptidase (-A, -N, -M, -B); B1/B2: Bradykinin receptors; CAGE: Chymostatin-sensitive AngII generating enzyme; CP: Carboxypeptidase; EP: Endopeptidase; Mas receptor: Ang(1-7) receptor type; Nep: Neprilysin; PEP: Prolyl endopeptidase; PCP: Prolylcarboxypeptidase; tPA: Tissue-type plasminogen activator. The picture is updated from Vaajanen et al[160].